amakuru

Ukurikije skeleton ya aza-BODIPY, NIR1001 ikubiyemo amatsinda atanga electron (urugero, 4-N, N-diphenylaminophenyl) kumwanya wa 2,6, ikora imiterere ya D-π-D ihuza1. Igishushanyo kigabanya icyuho cya HOMO-LUMO, gihindura igipimo cyo kwinjiza hejuru ya 1000 nm no kuzamura ihererekanyabubasha (ICT). Muri THF, NIR1001 yerekana ntarengwa ya fotone ebyiri (TPA) yambukiranya igice cya 37 GM, iterambere ryikubye kabiri kurenza inkomoko gakondo ya BODIPY. Ubuzima bwacyo bushimishije bwa 1,2 ps butuma inzibacyuho zidakwirakwira neza, bigatuma ikwirakwizwa na Photodynamic therapy (PDT).

Iharurwa rya DFT ryerekana ko uburyo bwo kohereza amafaranga ya NIR1001 buturuka kuri π-electron delocalisation hagati yabaterankunga niyakira. Guhindura Methoxy byongera imbaraga za NIR mumadirishya ya Phototherapeutic (650-900 nm), ikanonosora ibyiyumvo1. Ugereranije na AF irangi ya kaminuza ya Fudan, NIR1001 igumana uburemere buke bwa molekile (<500 Da) hamwe no gufotora hejuru ya 40%. Guhindura Carboxylation bitezimbere amazi (cLogD = 1.2), bigabanya adsorption idasanzwe muri sisitemu y'ibinyabuzima

3. Gukoresha ibinyabuzima
Muri bioimaging, hCG-conjugated probe hCG-NIR1001 igera kumashusho yinini cyane yerekana amashusho yintanga ngore na micro-metastase munsi ya 808 nm. Nubujyakuzimu bwa cm 3 muri NIR-II, burusha NIR-I inshuro eshatu, mugihe kugabanya fluorescence yibice 60%. Muburyo bwimvune yimbeba yimbeba, NIR1001 yerekana 85% gufata impyiko yihariye, ikamenya ibyangiritse inshuro esheshatu kuruta kugenzura macromolecular.
Kuri PDT, NIR1001 itanga ubwoko bwa ogisijeni ikora (ROS) kuri 0,85 μ mol / J munsi ya 1064 nm ya lazeri ya lazeri, bigatuma apoptose yibibyimba. Liposome-ikubiyemo NIR1001 nanoparticles (NPs) ikusanya inshuro 7.2 mubyimba kuruta irangi ryubusa, bikagabanya ingaruka zitari nziza.
4. Gukurikirana Inganda n’ibidukikije
Mubikorwa byinganda, NIR1001 yinjijwe muri Juhang Technology's SupNIR-1000 isesengura imbuto, gusuzuma inyama, no gutunganya itabi. Ikorera mu ntera ya 900-1700 nm, icyarimwe ipima ibirimo isukari, ubushuhe, hamwe n ibisigisigi byica udukoko mu masegonda 30 hamwe na ± (50ppm + 5% gusoma). Mu byuma bya moteri ya CO2 (ACDS-1001), NIR1001 ituma ikurikiranwa ryigihe hamwe na T90≤25s yo gusubiza hamwe nigihe cyimyaka 15.
Kugirango hamenyekane ibidukikije, iperereza rya NIR1001 ryerekana ibyuma biremereye mumazi. Muri pH 6.5-8.0, ubukana bwa fluorescence bufitanye isano neza na Hg²⁺ yibanze (0.1-10 μM) hamwe nimbibi yo gutahura 0,05 μM, irenze uburyo bwa colimetric nuburyo bubiri bwubunini.
5. Guhanga udushya no gucuruza
Ibikoresho bya Qingdaoikoresha synthesis ikomeza kugirango itange NIR1001 kuri 99.5% yera, hamwe na kg 50 / ubushobozi. Ukoresheje reaction ya microchannel, igihe cya Knoevenagel cyagabanutse kuva kumasaha 12 kugeza kuminota 30, bigabanya ingufu za 60%. ISO 13485 yemewe na NIR1001 yiganje ku isoko ryibinyabuzima.